Cart
sales@molnova.com
Gefitinib
CAS No. 184475-35-2
Gefitinib ( ZD-1839 )
Catalog No. M12848 CAS No. 184475-35-2
A potent, selective, orally active EGFR inhibitor with IC50 of 23 nM; inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 45 | In Stock |
|
| 500MG | 51 | In Stock |
|
| 1G | 67 | In Stock |
|
Biological Information
-
Product NameGefitinib
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, orally active EGFR inhibitor with IC50 of 23 nM; inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM.
-
DescriptionA potent, selective, orally active EGFR inhibitor with IC50 of 23 nM; inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM; blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50 of 0.2-0.4 uM; significantly decreases EGFRvIII phosphotyrosine load, EGFRvIII-mediated proliferation and anchorage-independent growth; has been used to treat advanced (or recurrent) non-small cell lung cancer.Lung Cancer Approved
-
SynonymsZD-1839
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorTyr1173 (NR6W cells); Tyr1173 (NR6wtEGFR cells); Tyr992 (NR6W cells); Tyr992 (NR6wtEGFR cells)
-
Research AreaCancer
-
IndicationLung Cancer
Chemical Information
-
CAS Number184475-35-2
-
Formula Weight446.90
-
Molecular FormulaC22H24ClFN4O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 30 mg/mL
-
SMILESCOC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4
-
Chemical Name4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Barker AJ, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1911-4.
2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.
3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.
2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.
3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.
molnova catalog
related products
-
BMS-599626 hydrochlo...
BMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
-
(1R,2R)-Trans-N-Boc-...
Cyclohexanediamine has a potential of anticancer activity.
-
Nimotuzumab
Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).
