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Gefitinib
CAS No. 184475-35-2
Gefitinib ( ZD-1839 )
Catalog No. M12848 CAS No. 184475-35-2
A potent, selective, orally active EGFR inhibitor with IC50 of 23 nM; inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 45 | In Stock |
|
| 500MG | 51 | In Stock |
|
| 1G | 67 | In Stock |
|
Biological Information
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Product NameGefitinib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally active EGFR inhibitor with IC50 of 23 nM; inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM.
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DescriptionA potent, selective, orally active EGFR inhibitor with IC50 of 23 nM; inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM; blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50 of 0.2-0.4 uM; significantly decreases EGFRvIII phosphotyrosine load, EGFRvIII-mediated proliferation and anchorage-independent growth; has been used to treat advanced (or recurrent) non-small cell lung cancer.Lung Cancer Approved
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SynonymsZD-1839
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PathwayAngiogenesis
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TargetEGFR
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RecptorTyr1173 (NR6W cells); Tyr1173 (NR6wtEGFR cells); Tyr992 (NR6W cells); Tyr992 (NR6wtEGFR cells)
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number184475-35-2
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Formula Weight446.90
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Molecular FormulaC22H24ClFN4O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESCOC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4
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Chemical Name4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barker AJ, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1911-4.
2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.
3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.
2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.
3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.
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