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Gamma-Methylleucine

CAS No. 57224-50-7

Gamma-Methylleucine ( gamma-Methyl-L-leucine; L-Neopentylglycine; 2-Amino-3-tert-butylpropionic acid )

Catalog No. M27985 CAS No. 57224-50-7

Gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gamma-Methylleucine
  • Note
    Research use only, not for human use.
  • Brief Description
    Gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions.
  • Description
    Gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions.(In Vivo):gamma-Methylleucine improved the binding affinity of the peptide for Y2R but also increased its anorectic activity in lean mice . Gamma-methylleucine resulted in loss of or significantly decreased the biological activity of ET-1, while high affinity for the ETA (IC50 = 0.42-0.70 nM) and ETB (IC50 = 0.17-0.43 nM) receptor was retained . Gamma-methylleucine was shown to have high antagonist activitiesin Sarafotoxin S6c-induced vasoconstriction of rabbit pulmonary artery (ET-1: pA2 8.4) and have the desirable characteristic of possessing no agonist activity at either receptor subtype .
  • Synonyms
    gamma-Methyl-L-leucine; L-Neopentylglycine; 2-Amino-3-tert-butylpropionic acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    57224-50-7
  • Formula Weight
    145.2
  • Molecular Formula
    C7H15NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)(C)C[C@H](N)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Son MJ, et al. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming. Exp Mol Med. 2018 Dec 6;50(12):160.
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