Galiellalactone

Research use only, not for human use.

A small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM.

A small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM, blocks the binding of the activated STAT3 dimers to DNA; induces apoptosis of p-Stat3 positive PCa cells, and Stat3-mediated transcription with IC50 of 5 uM, reduces the expression of Bcl-2, Bcl-x(L), c-myc, and cyclin D1; covalently binds to one or more cysteines in STAT3 and inhibits STAT3 binding to DNA and thus blocks STAT3 signaling without affecting phosphorylation; reduces tumor growth and decreases lymph node metastases in mice model of prostate cancer.

Galiellalactone

JAK/STAT Signaling

STAT

STAT

——

——

133613-71-5

194.20

C11H14O3

>98% (HPLC)

——

O=C1C2=C[C@@H](C)C[C@@]3([H])CC[C@@]([C@@]23O)([H])O1

(7bS)-5,5aR,6,7,7aR,7b-hexahydro-7b-hydroxy-4S-methyl-indeno[1,7-bc]furan-2(4H)-one

(-20℃)

With Ice Pack

≥ 2 years