Gabazine

CAS No. 104104-50-9

Gabazine( SR95531 )

Catalog No. M20907 CAS No. 104104-50-9

Gabazine is an antagonist of GABAA receptors (Ki : 74-150 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 Get Quote
10MG 65 Get Quote
25MG 129 Get Quote
50MG 245 Get Quote
100MG 439 Get Quote
200MG 593 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Gabazine
  • Note
    Research use only, not for human use.
  • Brief Description
    Gabazine is an antagonist of GABAA receptors (Ki : 74-150 nM).
  • Description
    Gabazine is an antagonist of GABAA receptors (Ki : 74-150 nM).
  • In Vitro
    Both bicuculline and Gabazine (SR 95531) have been characterized as competitive inhibitors of GABA binding to the GABAA receptor. Gabazine is more potent than bicuculline at blocking currents elicited by GABA, with an IC50 for currents elicited by 3 μM GABA of ~0.2 μM and a Hill coefficient of 1.0. Gabazine reduces the currents elicited by 10 μM alphaxalone by ~30%, for responses of receptors containing wildtype β2 subunits. The concentration of Gabazine requires producing half the maximal block is ~0.2 μM. Gabazine also could only produce a partial block of currents gated by 300 μM pentobarbital. The maximal reduction, again, is ~30%, and the concentration of Gabazine required to produce half the maximal block is ~0.15 μM.
  • In Vivo
    ——
  • Synonyms
    SR95531
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GABAA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    104104-50-9
  • Formula Weight
    368.23
  • Molecular Formula
    C15H18BrN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:75 mg/mL (203.68 mM)
  • SMILES
    Br.COc1ccc(-c2ccc(=N)n(CCCC(=O)O)n2)cc1
  • Chemical Name
    2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mendu S K Amol B Zhe J et al. Different Subtypes of GABA-A Receptors Are Expressed in Human Mouse and Rat T Lymphocytes[J]. PLoS ONE 2012 7(8):e42959-.
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