Gabazine
CAS No. 104104-50-9
Gabazine( SR95531 )
Catalog No. M20907 CAS No. 104104-50-9
Gabazine is an antagonist of GABAA receptors (Ki : 74-150 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 42 | Get Quote |
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10MG | 65 | Get Quote |
|
25MG | 129 | Get Quote |
|
50MG | 245 | Get Quote |
|
100MG | 439 | Get Quote |
|
200MG | 593 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameGabazine
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NoteResearch use only, not for human use.
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Brief DescriptionGabazine is an antagonist of GABAA receptors (Ki : 74-150 nM).
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DescriptionGabazine is an antagonist of GABAA receptors (Ki : 74-150 nM).
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In VitroBoth bicuculline and Gabazine (SR 95531) have been characterized as competitive inhibitors of GABA binding to the GABAA receptor. Gabazine is more potent than bicuculline at blocking currents elicited by GABA, with an IC50 for currents elicited by 3 μM GABA of ~0.2 μM and a Hill coefficient of 1.0. Gabazine reduces the currents elicited by 10 μM alphaxalone by ~30%, for responses of receptors containing wildtype β2 subunits. The concentration of Gabazine requires producing half the maximal block is ~0.2 μM. Gabazine also could only produce a partial block of currents gated by 300 μM pentobarbital. The maximal reduction, again, is ~30%, and the concentration of Gabazine required to produce half the maximal block is ~0.15 μM.
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In Vivo——
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SynonymsSR95531
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PathwayOthers
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TargetOther Targets
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RecptorGABAA
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Research Area——
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Indication——
Chemical Information
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CAS Number104104-50-9
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Formula Weight368.23
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Molecular FormulaC15H18BrN3O3
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Purity>98% (HPLC)
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SolubilityDMSO:75 mg/mL (203.68 mM)
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SMILESBr.COc1ccc(-c2ccc(=N)n(CCCC(=O)O)n2)cc1
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Chemical Name2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mendu S K Amol B Zhe J et al. Different Subtypes of GABA-A Receptors Are Expressed in Human Mouse and Rat T Lymphocytes[J]. PLoS ONE 2012 7(8):e42959-.
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