Cart
sales@molnova.com
Home - Products - Angiogenesis - CDK - GW-8510

GW-8510

CAS No. 222036-17-1

GW-8510( GW8510 | GW 8510 )

Catalog No. M13542 CAS No. 222036-17-1

GW-8510 (GW8510) is a?potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.

GW-8510 (GW8510) is a?potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
50MG 896 In Stock
100MG 1341 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    GW-8510
  • Note
    Research use only, not for human use.
  • Brief Description
    GW-8510 (GW8510) is a?potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.
  • Description
    GW-8510 (GW8510) is a?potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays; only inhibits CDK5 on cultured neurons; downregulates the expression of XIAP and no detectable effect on the expression of Bax, Bak, or Bcl2; also demonstrates neuroprotective ability in MN9D cells in the presence of 1-methyl-4-phenylpyridium (MPP(+)).
  • In Vitro
    Cell Viability AssayCell Line:HCT116 cells Concentration:0.5, 1, 2, 4 μM Incubation Time:72 hours Result:Inhibited HCT116 cells growth.Western Blot Analysis Cell Line:HCT116 cells Concentration:1, 2, 4 μM Incubation Time:24 hours Result:Inhibited RRM2 expression.The reduction of RRM2 protein level can be reversed by MG132.
  • In Vivo
    ——
  • Synonyms
    GW8510 | GW 8510
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    222036-17-1
  • Formula Weight
    449.51
  • Molecular Formula
    C21H15N5O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (55.62 mM)
  • SMILES
    O=S(C1=CC=C(N/C=C2C(NC3=C\2C(SC=N4)=C4C=C3)=O)C=C1)(NC5=NC=CC=C5)=O
  • Chemical Name
    4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinylbenzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Johnson K, et al. J Neurochem. 2005 May;93(3):538-48. 2. Davis ST, et al. Science. 2001 Jan 5;291(5501):134-7. Retraction. [Science. 2002] 3. Wimalasena NK, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):857-63.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • CDK12 inhibitor 2

    CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.

  • ML141

    ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.

  • PF-562271

    PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays.

Sign In Join Free