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GW-8510
CAS No. 222036-17-1
GW-8510( GW8510 | GW 8510 )
Catalog No. M13542 CAS No. 222036-17-1
GW-8510 (GW8510) is a?potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 896 | In Stock |
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| 100MG | 1341 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGW-8510
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NoteResearch use only, not for human use.
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Brief DescriptionGW-8510 (GW8510) is a?potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.
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DescriptionGW-8510 (GW8510) is a?potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays; only inhibits CDK5 on cultured neurons; downregulates the expression of XIAP and no detectable effect on the expression of Bax, Bak, or Bcl2; also demonstrates neuroprotective ability in MN9D cells in the presence of 1-methyl-4-phenylpyridium (MPP(+)).
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In VitroCell Viability AssayCell Line:HCT116 cells Concentration:0.5, 1, 2, 4 μM Incubation Time:72 hours Result:Inhibited HCT116 cells growth.Western Blot Analysis Cell Line:HCT116 cells Concentration:1, 2, 4 μM Incubation Time:24 hours Result:Inhibited RRM2 expression.The reduction of RRM2 protein level can be reversed by MG132.
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In Vivo——
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SynonymsGW8510 | GW 8510
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number222036-17-1
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Formula Weight449.51
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Molecular FormulaC21H15N5O3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (55.62 mM)
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SMILESO=S(C1=CC=C(N/C=C2C(NC3=C\2C(SC=N4)=C4C=C3)=O)C=C1)(NC5=NC=CC=C5)=O
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Chemical Name4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinylbenzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johnson K, et al. J Neurochem. 2005 May;93(3):538-48.
2. Davis ST, et al. Science. 2001 Jan 5;291(5501):134-7. Retraction. [Science. 2002]
3. Wimalasena NK, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):857-63.
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