Cart
sales@molnova.com
GW-8510
CAS No. 222036-17-1
GW-8510 ( GW8510;GW 8510 )
Catalog No. M13542 CAS No. 222036-17-1
GW-8510 (GW8510) is apotent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 896 | Get Quote |
|
| 100MG | 1341 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGW-8510
-
NoteResearch use only, not for human use.
-
Brief DescriptionGW-8510 (GW8510) is apotent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.
-
DescriptionGW-8510 (GW8510) is apotent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays; only inhibits CDK5 on cultured neurons; downregulates the expression of XIAP and no detectable effect on the expression of Bax, Bak, or Bcl2; also demonstrates neuroprotective ability in MN9D cells in the presence of 1-methyl-4-phenylpyridium (MPP(+)).
-
SynonymsGW8510;GW 8510
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number222036-17-1
-
Formula Weight449.51
-
Molecular FormulaC21H15N5O3S2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=S(C1=CC=C(N/C=C2C(NC3=C\2C(SC=N4)=C4C=C3)=O)C=C1)(NC5=NC=CC=C5)=O
-
Chemical Name4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinylbenzenesulfonamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Johnson K, et al. J Neurochem. 2005 May;93(3):538-48.
2. Davis ST, et al. Science. 2001 Jan 5;291(5501):134-7. Retraction. [Science. 2002]
3. Wimalasena NK, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):857-63.
2. Davis ST, et al. Science. 2001 Jan 5;291(5501):134-7. Retraction. [Science. 2002]
3. Wimalasena NK, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):857-63.
molnova catalog
related products
-
ML141
ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
-
NSC 625987
NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
-
DASA-58
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
