Cart
sales@molnova.com
GSK854
CAS No. 1316059-00-3
GSK854( —— )
Catalog No. M33986 CAS No. 1316059-00-3
GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury, and adverse remodeling in the ischemic heart.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 149 | Get Quote |
|
| 5MG | 235 | Get Quote |
|
| 10MG | 377 | Get Quote |
|
| 25MG | 725 | Get Quote |
|
| 50MG | 1086 | Get Quote |
|
| 100MG | 1683 | Get Quote |
|
| 500MG | 3375 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGSK854
-
NoteResearch use only, not for human use.
-
Brief DescriptionGSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury, and adverse remodeling in the ischemic heart.
-
DescriptionGSK854 is a potent Inhibitor of Troponin I-Interacting Kinase (TNNI3K). GSK854 is a suitable lead for identifying new cardiac medicines and have been employed as in vivo tools in investigational studies aimed at defining the role of TNNI3K within heart failure.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1316059-00-3
-
Formula Weight482.96
-
Molecular FormulaC18H19ClN6O4S2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (517.64 mM; Ultrasonic )
-
SMILESCCS(=O)(=O)c1ccc(cc1Nc1cc(Nc2ccc(Cl)cn2)ncn1)S(=O)(=O)NC
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Philp J, et al. 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors. J Med Chem. 2018;61(7):3076-3088.?
molnova catalog
related products
-
HFY-4A
HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.
-
Mepazine
Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM.
-
Vitamin E succinate
Vitamin E succinate (D-alpha-Tocopherol Succinate) is an antioxidant tocopherol that belongs to the vitamin E class of compounds Vitamin E succinate has antitumor activity, induces apoptosis, and is used as an adjuvant in the treatment of cancer and in the synthesis of INVITE, a biocoupling compound.
