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Mepazine

CAS No. 60-89-9

Mepazine ( Pecazine )

Catalog No. M26752 CAS No. 60-89-9

Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 35 Get Quote
10MG 50 Get Quote
25MG 84 Get Quote
50MG 129 Get Quote
100MG 178 Get Quote
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Biological Information

  • Product Name
    Mepazine
  • Note
    Research use only, not for human use.
  • Brief Description
    Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM.
  • Description
    Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.(In Vitro):Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.(In Vivo):In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration.
  • Synonyms
    Pecazine
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Androgen Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    60-89-9
  • Formula Weight
    310.5
  • Molecular Formula
    C19H22N2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Toure BAKARY-BARRY, et al. Indole compounds as androgen receptor modulators.WO2022020342
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