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KRH-1636
CAS No. 568526-77-2
KRH-1636( KRH1636 | KRH 1636 )
Catalog No. M15068 CAS No. 568526-77-2
A potent, selective inhibitor of CXCR4 with IC50 of 13 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | In Stock |
|
| 50MG | 1782 | In Stock |
|
| 100MG | 2250 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKRH-1636
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective inhibitor of CXCR4 with IC50 of 13 nM.
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DescriptionA potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5; completely inhibits X4 HIV-1 (IIIB strain) replication in MT-4 cells with EC50 of 19.3 nM and EC90 of 47.8 nM, without cytotoxic concentration (CC50>400 uM), also has effectivity against HTLV-IIIB and three clinical isolates in PBMCs including YU-6 (EC50=46 nM), but not R5 HIV-1, YU-1, YU-2; selectively blocks CXCR4-mediated Ca2+ signaling, blocks X4 HIV-1 replication in human PBL/SCID mice.
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In Vitro——
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In Vivo——
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SynonymsKRH1636 | KRH 1636
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number568526-77-2
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Formula Weight551.695
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Molecular FormulaC32H37N7O2
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Purity>98% (HPLC)
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Solubility——
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SMILESNC(NCCC[C@@H](C(N[C@H](C1=C2C=CC=CC2=CC=C1)C)=O)NC(C3=CC=C(C=C3)CNCC4=NC=CC=C4)=O)=N
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Chemical NameN-((S)-5-guanidino-1-(((S)-1-(naphthalen-1-yl)ethyl)amino)-1-oxopentan-2-yl)-4-(((pyridin-2-ylmethyl)amino)methyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ichiyama K, et al. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4185-90.
2. Murakami T, et al. Antimicrob Agents Chemother. 2009 Jul;53(7):2940-8.
3. Zachariassen ZG, et al. J Med Chem. 2015 Oct 22;58(20):8141-53.
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