GSK699 ( GSK-699;GSK 699 )

Catalog No. M13616 CAS No. 2260944-68-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK699
Note

Research use only, not for human use.
Brief Description

GSK699 (GSK-699) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells.
Description

GSK699 (GSK-699) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells; also potently induces robust and concentration-dependent degradation of PCAF and GCN5 in both macrophages and monocyte-derived dendritic cells (DCs), potently modulate the expression of multiple inflammatory mediators in LPS-stimulated macrophages and dendritic cells.
Synonyms

GSK-699;GSK 699
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

2260944-68-9
Formula Weight

895.86
Molecular Formula

C45H51BrN8O7
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N(CCCN(C1=CC=C(CCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)C=C1)C)C)C5=CC=C([C@@H]6CN(C)C[C@H](NC(C=NN7C)=C(Br)C7=O)C6)C=C5
Chemical Name

4-((3R,5R)-5-((5-bromo-1-methyl-6-oxo-1,6-dihydropyridazin-4-yl)amino)-1-methylpiperidin-3-yl)-N-(3-((4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)propyl)phenyl)(methyl)amino)propyl)-N-methylbenzamide

1. Bassi ZI, et al. ACS Chem Biol. 2018 Oct 19;13(10):2862-2867.

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