GSK2593074A ( GSK'074;GSK-2593074A )

Catalog No. M11349 CAS No. 1337531-06-2

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Product Name

GSK2593074A
Note

Research use only, not for human use.
Brief Description

GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor.
Description

GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively; potently inhibits necroptosis in various cell types (IC50=3 nM both in MOVAS and L929 cells), blocks necroptosis signaling pathway; inhibits RIP3-dependent RIP1-independent necroptosis and inflammation, but does not induce apoptosis; attenuates cell death and inflammation in calcium phosphate injured aortae.
Synonyms

GSK'074;GSK-2593074A
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIP kinase
Research Area

——
Indication

——

CAS Number

1337531-06-2
Formula Weight

465.58
Molecular Formula

C27H23N5OS
Purity

>98% (HPLC)
Solubility

——
SMILES

CN1N=CC(C2=CN=C(N)C3=C2SC=C3C4=CC5=C(N(C(CC6=CC=CC=C6)=O)CC5)C=C4)=C1
Chemical Name

1-(5-(4-amino-7-(1-methyl-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)indolin-1-yl)-2-phenylethan-1-one

1. Zhou T, et al. Cell Death Dis. 2019 Mar 6;10(3):226.

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