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GSK189254A

CAS No. 720690-73-3

GSK189254A ( GSK189254 )

Catalog No. M24731 CAS No. 720690-73-3

GSK189254A is a potent and specific histamine H3 receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK189254A
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK189254A is a potent and specific histamine H3 receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3).
  • Description
    GSK189254A is a potent and specific histamine H3 receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3).
  • Synonyms
    GSK189254
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Mouse H3 receptor;Human H3 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    720690-73-3
  • Formula Weight
    351.4
  • Molecular Formula
    C21H25N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:24 mg/mL (68.29 mM; Need ultrasonic)
  • SMILES
    CNC(=O)C1=CN=C(C=C1)OC2=CC3=C(CCN(CC3)C4CCC4)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45.
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