GSK-340
CAS No. 2222509-79-5
GSK-340 ( GSK340;GSK 340 )
Catalog No. M13548 CAS No. 2222509-79-5
GSK-340 is a potent, selective inhibitor of second bromodomains of the BET family (BD2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGSK-340
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-340 is a potent, selective inhibitor of second bromodomains of the BET family (BD2).
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DescriptionGSK-340 is a potent, selective inhibitor of second bromodomains of the BET family (BD2) with pKd of 8.18, 7.49, 7.72 and 7.68 for BRD4 BD2, BRD3 BD2, BRD2 BD2 and BRD4T BD2, respectively; displays 229-, 40-, 48- and 91-fold selectivity over the responding BD1, >100-fold selectivity over TAF1, WRD9, ATAD2A/B and other bromodomains (pKd<5.0); inhibits BRD4 BD2, BRD3 BD2, BRD2 BD2 and BRD4T BD2 with pIC50 of 7.2, 6.5, 7.3 and 6.7, respectively; inhibits release of the MCP-1 cytokine in human PBMCs (pIC50=7.4) and whole blood; GSK-340 is an useful in vitro tool molecule for investigation into the biological role of the BD2 domains.
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SynonymsGSK340;GSK 340
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number2222509-79-5
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Formula Weight417.55
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Molecular FormulaC26H31N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(S)-1-(2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydroquinoxalin-1(2H)-yl)ethan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Law RP, et al. J Med Chem. 2018 May 3. doi: 10.1021/acs.jmedchem.7b01666.
molnova catalog
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