GSK046 ( iBET-BD2 )

Catalog No. M24132 CAS No. 2474876-09-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK046
Note

Research use only, not for human use.
Brief Description

GSK046 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins(IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively).
Description

GSK046 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins(IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively). It has immunomodulatory activity.
Synonyms

iBET-BD2
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

BRD2-BD2;BRD3-BD2;BRD4-BD2;BRDT-BD2
Research Area

——
Indication

——

CAS Number

2474876-09-8
Formula Weight

414.5
Molecular Formula

C23H27FN2O4
Purity

>98% (HPLC)
Solubility

DMSO:83.33 mg/mL?(201.05 mM;?Need ultrasonic)
SMILES

O=C(N[C@@H]1CC[C@@H](O)CC1)C2=CC(O[C@H](C3=CC=CC=C3)C)=C(NC(C)=O)C(F)=C2
Chemical Name

——

1.Omer G, et, al. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science. 2020 Apr 24; 368(6489): 387-394.

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