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GSK-8999

CAS No. 1422355-59-6

GSK-8999( GSK-2578999 )

Catalog No. M11773 CAS No. 1422355-59-6

GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK-8999
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor.
  • Description
    GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively; shows high potency against 57 of 62 isolates demonstrating an improvement over the first generation maturation inhibitor BVM; has a mechanism of action consistent with inhibition of the proteolytic cleavage of CA-SP1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK-2578999
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    1422355-59-6
  • Formula Weight
    776.44
  • Molecular Formula
    C46H62ClNO7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)C(C)(C)CC(O[C@@H](CC[C@]1(C)[C@@]2([H])CC[C@@]34[H])C(C)(C)[C@]1([H])CC[C@@]2(C)[C@]3(C)CC[C@]5(C(C(NC6(C7=CC=C(Cl)C=C7)CC6)=O)=O)C4=C(C(C)C)C(C5)=O)=O
  • Chemical Name
    (3β)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-N-[1-(4-chlorophenyl)cyclopropyl]-α,21-dioxo-28-norlup-18-ene-17-acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tang J, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2689-2694.
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