GSK-8999( GSK-2578999 )

Catalog No. M11773 CAS No. 1422355-59-6

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Product Name

GSK-8999
Note

Research use only, not for human use.
Brief Description

GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor.
Description

GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively; shows high potency against 57 of 62 isolates demonstrating an improvement over the first generation maturation inhibitor BVM; has a mechanism of action consistent with inhibition of the proteolytic cleavage of CA-SP1.
In Vitro

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In Vivo

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Synonyms

GSK-2578999
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

Infection
Indication

——

CAS Number

1422355-59-6
Formula Weight

776.44
Molecular Formula

C46H62ClNO7
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(O)C(C)(C)CC(O[C@@H](CC[C@]1(C)[C@@]2([H])CC[C@@]34[H])C(C)(C)[C@]1([H])CC[C@@]2(C)[C@]3(C)CC[C@]5(C(C(NC6(C7=CC=C(Cl)C=C7)CC6)=O)=O)C4=C(C(C)C)C(C5)=O)=O
Chemical Name

(3β)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-N-[1-(4-chlorophenyl)cyclopropyl]-α,21-dioxo-28-norlup-18-ene-17-acetamide

1. Tang J, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2689-2694.

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