GSK-467

CAS No. 1628332-52-4

GSK-467( GSK467 )

Catalog No. M12429 CAS No. 1628332-52-4

GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 160 Get Quote
10MG 237 Get Quote
25MG 475 Get Quote
50MG 689 Get Quote
100MG 963 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    GSK-467
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM.
  • Description
    GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members; increases the rate of apoptosis in myeloma cells.
  • In Vitro
    Cell Proliferation Assay Cell Line:Human multiple myeloma tumor cell line MM.1S Concentration:0-100 μM Incubation Time:6 days Result:Showed antiproliferative effect with an IC50 of >50 μM.
  • In Vivo
    ——
  • Synonyms
    GSK467
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Histone Demethylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1628332-52-4
  • Formula Weight
    319.32
  • Molecular Formula
    C17H13N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 20.83 mg/mL 65.23 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C1C2=C(C=NC=C2)N=C(OC3=CN(CC4=CC=CC=C4)N=C3)N1
  • Chemical Name
    2-[(1-Benzyl-1H-pyrazol-4-yl)oxy]-pyrido-[3,4-d]pyrimidin-4(3H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45. 2. Westaway SM, et al. J Med Chem. 2016 Feb 25;59(4):1370-87.
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