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Home - Products - Cell Cycle/DNA Damage - PLK - GSK-461364

GSK-461364

CAS No. 929095-18-1

GSK-461364 ( GSK-461364A )

Catalog No. M16654 CAS No. 929095-18-1

A potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 40 In Stock
5MG 61 In Stock
10MG 113 In Stock
25MG 195 In Stock
50MG 354 In Stock
100MG 528 In Stock
200MG 755 In Stock
500MG 1152 In Stock
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Biological Information

  • Product Name
    GSK-461364
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM.
  • Description
    A potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM; >390-fold greater selectivity for Plk1 than for Plk2 and Plk3 and 1,000-fold greater selectivity than for a panel of 48 other kinases; shows antiproliferative activity against >120 tumor cell lines and potently inhibits the proliferation with IC50s of <100 nM; shows clear antitumor activity in human tumor xenograft models.Blood Cancer Phase 1 Clinical
  • Synonyms
    GSK-461364A
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PLK
  • Recptor
    PLK1
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    929095-18-1
  • Formula Weight
    543.60
  • Molecular Formula
    C27H28F3N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=C(O[C@@H](C2=CC=CC=C2C(F)(F)F)C)C=C(N3C=NC4=CC=C(CN5CCN(C)CC5)C=C34)S1)N
  • Chemical Name
    2-Thiophenecarboxamide, 5-[6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Olmos D, et al. Clin Cancer Res. 2011 May 15;17(10):3420-30.
2. Gilmartin AG, et al. Cancer Res. 2009 Sep 1;69(17):6969-77.
3. Degenhardt Y, et al. Mol Cancer Ther. 2010 Jul;9(7):2079-89.
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