AU1 ( GSK 1379725A )

Catalog No. M12752 CAS No. 1802251-00-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AU1
Note

Research use only, not for human use.
Brief Description

AU1 (GSK 1379725A) is the first selective small molecule inhibitor of BPTF bromodomain (bromodomain PHD finger transcription factor) with Kd of 2.8 uM in a cell-based reporter assay.
Description

AU1 (GSK 1379725A) is the first selective small molecule inhibitor of BPTF bromodomain (bromodomain PHD finger transcription factor) with Kd of 2.8 uM in a cell-based reporter assay, shows no binding activity for Brd4; interferes with its regulatory activity in cultured cells.
Synonyms

GSK 1379725A
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

Other Indications
Indication

——

CAS Number

1802251-00-8
Formula Weight

450.47
Molecular Formula

C23H23FN6O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(OC)C1=CC=CC(NC(NC2CN(C3=NC(NC4=CC=C(F)C=C4)=NC=C3)CC2)=O)=C1
Chemical Name

Benzoic acid, 3-[[[[1-[2-[(4-fluorophenyl)amino]-4-pyrimidinyl]-3-pyrrolidinyl]amino]carbonyl]amino]-, methyl ester

1. Urick AK, et al. ACS Chem Biol. 2015 Oct 16;10(10):2246-56.

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