GSK-256066

CAS No. 801312-28-7

GSK-256066 ( GSK256066;GSK 256066 )

Catalog No. M16000 CAS No. 801312-28-7

A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 42 Get Quote
5MG 68 Get Quote
10MG 115 Get Quote
25MG 237 Get Quote
50MG 385 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    GSK-256066
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively.
  • Description
    A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively; displays >380,000-fold selectivity over PDE1/2/3/5/6/7; inhibits TNFα production by lLPS-stimulated human peripheral blood monocytes with IC50 of 0.01 nM; inhibites LPS-induced pulmonary neutrophilia with ED50 of 1.1 ug/kg (aqueous suspension) and 2.9 ug/kg (dry powder formulation) in rats.COPD Phase 2 Discontinued
  • Synonyms
    GSK256066;GSK 256066
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE4B
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    801312-28-7
  • Formula Weight
    518.58
  • Molecular Formula
    C27H26N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 5.2 mg/mL
  • SMILES
    CC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C
  • Chemical Name
    3-Quinolinecarboxamide, 6-[[3-[(dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Woodrow MD, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5261-5.
2. Tralau-Stewart CJ, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):145-54.
3. Nials AT, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):137-44.
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