GSK-2269557 ( GSK2269557;Nemiralisib )

Catalog No. M11027 CAS No. 1254036-71-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK-2269557
Note

Research use only, not for human use.
Brief Description

GSK-2269557 is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).
Description

GSK-2269557 is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9); displays >1000 fold selectivity versus other PI3K isoforms; inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.2 and 8.1, respectively, in a human lung parenchyma assay; shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=67ug/kg).COPD Phase 2 Clinical
Synonyms

GSK2269557;Nemiralisib
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Inflammation/Immunology
Indication

COPD

CAS Number

1254036-71-9
Formula Weight

440.54
Molecular Formula

C26H28N6O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 31 mg/mL
SMILES

CC(N1CCN(CC2=CN=C(C3=CC(C4=CC=CC5=C4C=CN5)=CC6=C3C=NN6)O2)CC1)C
Chemical Name

1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-

1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.

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