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Home - Products - GPCR/G Protein - Antibacterial - GSK-2140944

GSK-2140944

CAS No. 1075236-89-3

GSK-2140944 ( Gepotidacin;GSK2140944 )

Catalog No. M10308 CAS No. 1075236-89-3

GSK-2140944 (Gepotidacin) is a novel potent, selective bacterial type II topoisomerase inhibitor in development for the treatment of conventional and biothreat pathogens.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GSK-2140944
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK-2140944 (Gepotidacin) is a novel potent, selective bacterial type II topoisomerase inhibitor in development for the treatment of conventional and biothreat pathogens.
  • Description
    GSK-2140944 (Gepotidacin) is a novel potent, selective bacterial type II topoisomerase inhibitor in development for the treatment of conventional and biothreat pathogens, including Gram-positive pathogens and MRSA; shows antibacterial activity against MSSA and MRSA isolates (MIC90=0.5 ug/ml).Bacterial Infection Phase 2 Clinical
  • Synonyms
    Gepotidacin;GSK2140944
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    1075236-89-3
  • Formula Weight
    448.53
  • Molecular Formula
    C24H28N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 7.14 mg/mL 15.92 mM
  • SMILES
    O=C(C=NC(C=C1)=C23)N3[C@H](CN4CCC(NCC(N=C5)=CC6=C5OCCC6)CC4)CN2C1=O
  • Chemical Name
    (2R)-2-[[4-[[(3,4-Dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methyl]amino]-1-piperidinyl]methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bax BD, et al. Nature. 2010 Aug 19;466(7309):935-40.
2. Biedenbach DJ, et al. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1918-23.
3. So W, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4956-61.
4. Farrell DJ, et al. Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02047-16.
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