Azathramycin ( Azaerythromycin A;Desmethyl Azithromycin )

Catalog No. M15903 CAS No. 76801-85-9

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Product Name

Azathramycin
Note

Research use only, not for human use.
Brief Description

A macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer.
Description

A macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer; enhances paclitaxel and cisplatin in non-small cell lung cancer.Bacterial Infection Approved
Synonyms

Azaerythromycin A;Desmethyl Azithromycin
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibiotic
Research Area

Infection
Indication

Bacterial Infection

CAS Number

76801-85-9
Formula Weight

734.96
Molecular Formula

C37H70N2O12
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC[C@@H]1[C@@]([C@@H]([C@H](NC[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O
Chemical Name

1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,1

1. Li F, et al. Oncol Lett. 2017 Jul;14(1):89-96.
2. Chu DJ, et al. Genet Mol Res. 2014 Apr 14;13(2):2796-805.

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