GS-9191( —— )

Catalog No. M34081 CAS No. 859209-84-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GS-9191
Note

Research use only, not for human use.
Brief Description

GS-9191 is a potent inhibitor of DNA polymerase alpha and ? , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , which penetrates the skin and is metabolized in the epithelium to an active nucleoside triphosphate analogue.
Description

GS-9191 is a potent inhibitor of DNA polymerase alpha and ? , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , which penetrates the skin and is metabolized in the epithelium to an active nucleoside triphosphate analogue.GS-9191 has antiproliferative activity and reduces the size of papillomas in a dose-related manner.GS-9191 may be useful in the treatment of HPV-induced lesions.
In Vitro

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In Vivo

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Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis
Research Area

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Indication

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CAS Number

859209-84-0
Formula Weight

734.82
Molecular Formula

C37H51N8O6P
Purity

>98% (HPLC)
Solubility

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SMILES

C(COCP(N[C@@H](CC1=CC=CC=C1)C(OCC(C)C)=O)(N[C@@H](CC2=CC=CC=C2)C(OCC(C)C)=O)=O)N3C=4C(=C(NC5CC5)N=C(N)N4)N=C3
Chemical Name

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