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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - CX-3543

CX-3543

CAS No. 865311-47-3

CX-3543( Quarfloxin | Itarnafloxin )

Catalog No. M16281 CAS No. 865311-47-3

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CX-3543
  • Note
    Research use only, not for human use.
  • Brief Description
    CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus.
  • Description
    CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.Blood Cancer Phase 2 Discontinued.
  • In Vitro
    Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines.Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM.
  • In Vivo
    ——
  • Synonyms
    Quarfloxin | Itarnafloxin
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    865311-47-3
  • Formula Weight
    604.67
  • Molecular Formula
    C35H33FN6O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (8.27 mM)
  • SMILES
    O=C(C1=CN2C3=C(C(N4C[C@H](C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
  • Chemical Name
    5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61. 2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32. 3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.
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