CX-3543( Quarfloxin | Itarnafloxin )

Catalog No. M16281 CAS No. 865311-47-3

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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5MG	241	Get Quote
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25MG	619	Get Quote
50MG	872	Get Quote
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Biological Information

Product Name

CX-3543
Note

Research use only, not for human use.
Brief Description

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus.
Description

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.Blood Cancer Phase 2 Discontinued.
In Vitro

Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines.Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM.
In Vivo

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Synonyms

Quarfloxin | Itarnafloxin
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis
Research Area

Cancer
Indication

Blood cancer

Chemical Information

CAS Number

865311-47-3
Formula Weight

604.67
Molecular Formula

C35H33FN6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 5 mg/mL (8.27 mM)
SMILES

O=C(C1=CN2C3=C(C(N4C[C@H](C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
Chemical Name

5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61. 2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32. 3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.

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