Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - 5-HT Receptor - GR-127935

GR-127935

CAS No. 148672-13-3

GR-127935 ( GR127935 )

Catalog No. M12051 CAS No. 148672-13-3

GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1143 Get Quote
50MG 2322 Get Quote
100MG 3060 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    GR-127935
  • Note
    Research use only, not for human use.
  • Brief Description
    GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.
  • Description
    GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor; displays >100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types; blocks porcine carotid vascular response to sumatriptan in vivo; orally bioavailable and centrally active.
  • Synonyms
    GR127935
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    148672-13-3
  • Formula Weight
    497.59
  • Molecular Formula
    C29H31N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
  • Chemical Name
    N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Clitherow JW, et al. J Med Chem. 1994 Jul 22;37(15):2253-7.
2. Knobelman DA, et al. J Pharmacol Exp Ther. 2001 Sep;298(3):1083-91.
3. De Vries P, et al. Br J Pharmacol. 1996 May;118(1):85-92.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AVN-322 free base

    A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.

  • Metoclopramide hydro...

    Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

  • Dalasetron Mesylate ...

    Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

Sign In Join Free