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Home - Products - Endocrinology/Hormones - 5-HT Receptor - GR-127935

GR-127935

CAS No. 148672-13-3

GR-127935 ( GR127935 )

Catalog No. M12051 CAS No. 148672-13-3

GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GR-127935
  • Note
    Research use only, not for human use.
  • Brief Description
    GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.
  • Description
    GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor; displays >100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types; blocks porcine carotid vascular response to sumatriptan in vivo; orally bioavailable and centrally active.
  • Synonyms
    GR127935
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    148672-13-3
  • Formula Weight
    497.59
  • Molecular Formula
    C29H31N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
  • Chemical Name
    N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Clitherow JW, et al. J Med Chem. 1994 Jul 22;37(15):2253-7.
2. Knobelman DA, et al. J Pharmacol Exp Ther. 2001 Sep;298(3):1083-91.
3. De Vries P, et al. Br J Pharmacol. 1996 May;118(1):85-92.
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