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GPI-1046
CAS No. 186452-09-5
GPI-1046( GPI1046 | GPI 1046 )
Catalog No. M12879 CAS No. 186452-09-5
GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 86 | In Stock |
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| 5MG | 132 | In Stock |
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| 10MG | 222 | In Stock |
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| 25MG | 376 | In Stock |
|
| 50MG | 536 | In Stock |
|
| 100MG | 777 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGPI-1046
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NoteResearch use only, not for human use.
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Brief DescriptionGPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.
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DescriptionGPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12; induces ARNT expression with subsequent activation of ALK3-dependent canonical BMP signaling responses and attenuates chronic organ failure in models of chronic kidney, but also cardiac and liver injuries; reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats.Parkinson Disease Discontinued.
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In Vitro——
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In Vivo——
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SynonymsGPI1046 | GPI 1046
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research AreaNeurological Disease
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IndicationParkinson Disease
Chemical Information
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CAS Number186452-09-5
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Formula Weight360.454
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Molecular FormulaC20H28N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (277.43 mM)
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SMILESCCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2
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Chemical Name3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sauer H, et al. Brain Res. 1999 Sep 18;842(1):109-18.
2. Burnett AL, et al. Urology. 2005 May;65(5):1003-7.
3. Sari Y, et al. Neuroscience. 2012 Dec 27;227:327-35.
4. Tampe B, et al. J Clin Invest. 2018 Apr 17. pii: 89632.
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