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Home - Products - PI3K/Akt/mTOR signaling - mTOR - GPI-1046

GPI-1046

CAS No. 186452-09-5

GPI-1046( GPI1046 | GPI 1046 )

Catalog No. M12879 CAS No. 186452-09-5

GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GPI-1046
  • Note
    Research use only, not for human use.
  • Brief Description
    GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.
  • Description
    GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12; induces ARNT expression with subsequent activation of ALK3-dependent canonical BMP signaling responses and attenuates chronic organ failure in models of chronic kidney, but also cardiac and liver injuries; reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats.Parkinson Disease Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GPI1046 | GPI 1046
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    mTOR
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    186452-09-5
  • Formula Weight
    360.454
  • Molecular Formula
    C20H28N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (277.43 mM)
  • SMILES
    CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2
  • Chemical Name
    3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sauer H, et al. Brain Res. 1999 Sep 18;842(1):109-18. 2. Burnett AL, et al. Urology. 2005 May;65(5):1003-7. 3. Sari Y, et al. Neuroscience. 2012 Dec 27;227:327-35. 4. Tampe B, et al. J Clin Invest. 2018 Apr 17. pii: 89632.
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