GPI-1046

CAS No. 186452-09-5

GPI-1046( GPI1046 | GPI 1046 )

Catalog No. M12879 CAS No. 186452-09-5

GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 86 In Stock
5MG 132 In Stock
10MG 222 In Stock
25MG 376 In Stock
50MG 536 In Stock
100MG 777 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    GPI-1046
  • Note
    Research use only, not for human use.
  • Brief Description
    GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.
  • Description
    GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12; induces ARNT expression with subsequent activation of ALK3-dependent canonical BMP signaling responses and attenuates chronic organ failure in models of chronic kidney, but also cardiac and liver injuries; reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats.Parkinson Disease Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GPI1046 | GPI 1046
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    mTOR
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    186452-09-5
  • Formula Weight
    360.454
  • Molecular Formula
    C20H28N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (277.43 mM)
  • SMILES
    CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2
  • Chemical Name
    3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sauer H, et al. Brain Res. 1999 Sep 18;842(1):109-18. 2. Burnett AL, et al. Urology. 2005 May;65(5):1003-7. 3. Sari Y, et al. Neuroscience. 2012 Dec 27;227:327-35. 4. Tampe B, et al. J Clin Invest. 2018 Apr 17. pii: 89632.
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