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Home - Products - PI3K/Akt/mTOR signaling - mTOR - WYE-125132

WYE-125132

CAS No. 1144068-46-1

WYE-125132( WYE-132 | WYE125132 )

Catalog No. M10513 CAS No. 1144068-46-1

A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    WYE-125132
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.
  • Description
    A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM; dispalys high selectivity (>5,000-fold) over PI3Ks, the PI3K-related kinases hSMG1 and ATR, and a panel of 230 protein kinases; inhibits mTORC1-dependent phosphorylation of S6K(T389) and mTORC2-dependent phosphorylation of AKT(S473), inhibits cancer cell proliferation, cell cycle progression, and induces apoptosis; shows potent single-agent antitumor activity against multiple cancer models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    WYE-132 | WYE125132
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    mTOR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1144068-46-1
  • Formula Weight
    519.5954
  • Molecular Formula
    C27H33N7O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 62 mg/mL
  • SMILES
    O=C(NC)NC1=CC=C(C2=NC(N3CC(O4)CCC4C3)=C5C(N(C(CC6)CCC76OCCO7)N=C5)=N2)C=C1
  • Chemical Name
    Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yu K, et al. Cancer Res. 2010 Jan 15;70(2):621-31.
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