WYE-125132

CAS No. 1144068-46-1

WYE-125132( WYE-132 | WYE125132 )

Catalog No. M10513 CAS No. 1144068-46-1

A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 247 In Stock
50MG 847 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    WYE-125132
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.
  • Description
    A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM; dispalys high selectivity (>5,000-fold) over PI3Ks, the PI3K-related kinases hSMG1 and ATR, and a panel of 230 protein kinases; inhibits mTORC1-dependent phosphorylation of S6K(T389) and mTORC2-dependent phosphorylation of AKT(S473), inhibits cancer cell proliferation, cell cycle progression, and induces apoptosis; shows potent single-agent antitumor activity against multiple cancer models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    WYE-132 | WYE125132
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    mTOR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1144068-46-1
  • Formula Weight
    519.5954
  • Molecular Formula
    C27H33N7O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 62 mg/mL
  • SMILES
    O=C(NC)NC1=CC=C(C2=NC(N3CC(O4)CCC4C3)=C5C(N(C(CC6)CCC76OCCO7)N=C5)=N2)C=C1
  • Chemical Name
    Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yu K, et al. Cancer Res. 2010 Jan 15;70(2):621-31.
molnova catalog
related products
  • RapaLink-1

    RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors.

  • NSC781406

    NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).

  • Seco Rapamycin

    Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin that does not affect mTOR.