Cart
sales@molnova.com
Home - Products - JAK/STAT Signaling - Pim - GNE-955

GNE-955

CAS No. 1527523-39-2

GNE-955( GNE955 )

Catalog No. M12142 CAS No. 1527523-39-2

GNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1143 In Stock
50MG 2322 In Stock
100MG 3060 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    GNE-955
  • Note
    Research use only, not for human use.
  • Brief Description
    GNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.
  • Description
    GNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively; shows only 3 kinases >80% inhibition (Pim-1, 100%; CLK1, 97%; Flt3, 82%) at 0.1 uM in a panel of 70 kinases; shows excellent bioavailability in rat.
  • In Vitro
    GNE-955 inhibits proliferation of MM.1S cells, with an IC50 value of 0.5 μM after 72 hours treatment.GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65), shows no effect on total BAD, S6 or 4EBP protein levels.
  • In Vivo
    ——
  • Synonyms
    GNE955
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    Pim
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1527523-39-2
  • Formula Weight
    415.501
  • Molecular Formula
    C23H25N7O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=NC(C2=NC=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=C4)C3=C2)=CN=C1
  • Chemical Name
    (S)-1-(3-methoxy-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)piperidin-3-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang X, et al. J Med Chem. 2017 May 25;60(10):4458-4473.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • CX-6258

    A potent, selective, and orally efficacious pan-Pim inhibitor with IC50 of 5/25/16 nM for Pim1/2/3, respectively.

  • Quercetagetin

    Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM).

  • Taprenepag

    Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM).

Sign In Join Free