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GNE-955

CAS No. 1527523-39-2

GNE-955( GNE955 )

Catalog No. M12142 CAS No. 1527523-39-2

GNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GNE-955
  • Note
    Research use only, not for human use.
  • Brief Description
    GNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.
  • Description
    GNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively; shows only 3 kinases >80% inhibition (Pim-1, 100%; CLK1, 97%; Flt3, 82%) at 0.1 uM in a panel of 70 kinases; shows excellent bioavailability in rat.
  • In Vitro
    GNE-955 inhibits proliferation of MM.1S cells, with an IC50 value of 0.5 μM after 72 hours treatment.GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65), shows no effect on total BAD, S6 or 4EBP protein levels.
  • In Vivo
    ——
  • Synonyms
    GNE955
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    Pim
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1527523-39-2
  • Formula Weight
    415.501
  • Molecular Formula
    C23H25N7O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=NC(C2=NC=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=C4)C3=C2)=CN=C1
  • Chemical Name
    (S)-1-(3-methoxy-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)piperidin-3-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang X, et al. J Med Chem. 2017 May 25;60(10):4458-4473.
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