
GNE-955
CAS No. 1527523-39-2
GNE-955( GNE955 )
Catalog No. M12142 CAS No. 1527523-39-2
GNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 1143 | In Stock |
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50MG | 2322 | In Stock |
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100MG | 3060 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameGNE-955
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively.
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DescriptionGNE-955 is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively; shows only 3 kinases >80% inhibition (Pim-1, 100%; CLK1, 97%; Flt3, 82%) at 0.1 uM in a panel of 70 kinases; shows excellent bioavailability in rat.
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In VitroGNE-955 inhibits proliferation of MM.1S cells, with an IC50 value of 0.5 μM after 72 hours treatment.GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65), shows no effect on total BAD, S6 or 4EBP protein levels.
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In Vivo——
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SynonymsGNE955
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PathwayJAK/STAT Signaling
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TargetPim
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RecptorPim
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1527523-39-2
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Formula Weight415.501
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Molecular FormulaC23H25N7O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=NC(C2=NC=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=C4)C3=C2)=CN=C1
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Chemical Name(S)-1-(3-methoxy-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)piperidin-3-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang X, et al. J Med Chem. 2017 May 25;60(10):4458-4473.
molnova catalog



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