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GNE-617
CAS No. 1362154-70-8
GNE-617( GNE-617 | GNE 617 | GNE617 )
Catalog No. M17972 CAS No. 1362154-70-8
GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 207 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-617
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.
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DescriptionGNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. Prolonged inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a strategy for targeting cancer metabolism.
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In Vitro——
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In Vivo——
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SynonymsGNE-617 | GNE 617 | GNE617
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PathwayMAPK/ERK Signaling
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TargetJNK
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RecptorNAMPT
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1362154-70-8
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Formula Weight427.43
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Molecular FormulaC21H15F2N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 42.85 mg/mL; 100.25 mM
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SMILESC1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F
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Chemical NameN-(4-((3,5-difluorophenyl)sulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19(24):6912-23.
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