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SU3327

CAS No. 40045-50-9

SU3327( —— )

Catalog No. M24361 CAS No. 40045-50-9

SU3327 is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 53 In Stock
10MG 87 In Stock
25MG 165 In Stock
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Biological Information

  • Product Name
    SU3327
  • Note
    Research use only, not for human use.
  • Brief Description
    SU3327 is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
  • Description
    SU3327 is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male BKS.Cg-+Leprdb/+Leprdb/OlaHsd db/db mice (11-week-old ) injected with insulin Dosage:25 mg/kg Administration:Intraperitoneal injection Result:Resulted in a statistically significant reduction in blood glucose levels.
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    JNK
  • Recptor
    JNK|JNK-JIP interactions
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    40045-50-9
  • Formula Weight
    261.3
  • Molecular Formula
    C5H3N5O2S3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (239.19 mM; Need ultrasonic)
  • SMILES
    Nc1nnc(Sc2ncc([N+]([O-])=O)s2)s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.De SK, et al. Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase. J Med Chem. 2009 Apr 9;52(7):1943-52.
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