Cart
sales@molnova.com
GNE-493
CAS No. 1033735-94-2
GNE-493 ( GNE493;GNE 493 )
Catalog No. M10163 CAS No. 1033735-94-2
A potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 152 | In Stock |
|
| 5MG | 259 | In Stock |
|
| 10MG | 339 | In Stock |
|
| 25MG | 561 | In Stock |
|
| 50MG | 790 | In Stock |
|
| 100MG | 1062 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGNE-493
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR.
-
DescriptionA potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR; displays 100-fold selective for PI3Kα over Aurora A, MLK1, Syk; has good PK profiles, and are efficacious in xenograft models; orally available.
-
SynonymsGNE493;GNE 493
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
RecptorPI3K
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1033735-94-2
-
Formula Weight372.44
-
Molecular FormulaC17H20N6O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 45 mg/mL
-
SMILESCC(O)(C1=CC2=NC(C3=CN=C(N)N=C3)=NC(N4CCOCC4)=C2S1)C
-
Chemical NameThieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sutherlin DP, et al. J Med Chem. 2010 Feb 11;53(3):1086-97.
molnova catalog
related products
-
TG6-10-1
TG6-10-1 is an EP2 antagonist.
-
IC-87114
A potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.
-
5S rRNA modificator
5S rRNA modificator, used in 5S rRNA RNA modification, is a suitable electrophile for 2’-hydroxyl acylation on structured RNA molecules.
