GNE-493 ( GNE493;GNE 493 )

Catalog No. M10163 CAS No. 1033735-94-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GNE-493
Note

Research use only, not for human use.
Brief Description

A potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR.
Description

A potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR; displays 100-fold selective for PI3Kα over Aurora A, MLK1, Syk; has good PK profiles, and are efficacious in xenograft models; orally available.
Synonyms

GNE493;GNE 493
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Cancer
Indication

——

CAS Number

1033735-94-2
Formula Weight

372.44
Molecular Formula

C17H20N6O2S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 45 mg/mL
SMILES

CC(O)(C1=CC2=NC(C3=CN=C(N)N=C3)=NC(N4CCOCC4)=C2S1)C
Chemical Name

Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-

1. Sutherlin DP, et al. J Med Chem. 2010 Feb 11;53(3):1086-97.

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