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GNE-220
CAS No. 1199590-75-4
GNE-220( GNE220 )
Catalog No. M10715 CAS No. 1199590-75-4
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
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| 50MG | 2322 | Get Quote |
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| 100MG | 3060 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGNE-220
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM.
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DescriptionGNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM; alters HUVEC sprout morphology, shifts the distribution of subcellular protrusion and increases total protrusions, dose-dependently increases the number of β1-integrin in long focal adhesions.
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In VitroGNE-220 also inhibits a few other kinases with IC50s of 9nM, 476 nM and 1.1μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs).
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In Vivo——
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SynonymsGNE220
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PathwayMAPK/ERK Signaling
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TargetMAP4K
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RecptorMAP4K
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Research Area——
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Indication——
Chemical Information
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CAS Number1199590-75-4
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Formula Weight438.539
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Molecular FormulaC25H26N8
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C2C(=NC(=N1)C3=CN(N=C3)C)C4=C(N2)N=CC(=C4)C5=CC=C(C=C5)N6CCN(CC6)C
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Chemical Name4-Methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vitorino P, et al. Nature. 2015 Mar 26;519(7544):425-30.
2. Gao X, et al. Cell Biosci. 2016 Oct 28;6:56. eCollection 2016.
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