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Home - Products - Immunology/Inflammation - IRAK - GLPG2534

GLPG2534

CAS No. 2095615-97-5

GLPG2534( —— )

Catalog No. M36623 CAS No. 2095615-97-5

GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 172 Get Quote
5MG 264 Get Quote
10MG 432 Get Quote
25MG 815 Get Quote
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Biological Information

  • Product Name
    GLPG2534
  • Note
    Research use only, not for human use.
  • Brief Description
    GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis.
  • Description
    GLPG2534 is an orally active and selective IRAK4 inhibitor, with IC50 values of 6.4 nM and 3.5 nM for human and mouse IRAK4. GLPG2534 can be used for the research of inflammatory skin diseases.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Psoriasis-like skin inflammation model, induced by IL-23 and IMQ Dosage:10 and 30 mg/kg Administration:p.o., b.i.d. 5 days Result:Reduced IL-23-induced expression of pathogenic cytokines such as Il17a (79%), Il22 (49%), Il1b (97%), and defensin Lcn2 (69%).
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    IRAK
  • Recptor
    IRAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2095615-97-5
  • Formula Weight
    424.45
  • Molecular Formula
    C21H24N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (235.60 mM; Ultrasonic )
  • SMILES
    N#CC1=CN=C(C=C1)N2C=NC=3C=C(OCCOCCO)C(=NC32)NC4CCOCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lavazais S, et al. IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases. Sci Transl Med. 2023 Feb 15;15(683):eabj3289. ?
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