Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - NADPH - GKT136901

GKT136901

CAS No. 955272-06-7

GKT136901( AK120765 )

Catalog No. M21598 CAS No. 955272-06-7

GKT136901 is an ?inhibitor of NOX1/4.It acts?as Selective and Direct Scavenger of Peroxynitrite.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 38 Get Quote
10MG 56 Get Quote
25MG 104 Get Quote
50MG 149 Get Quote
100MG 204 Get Quote
200MG 310 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    GKT136901
  • Note
    Research use only, not for human use.
  • Brief Description
    GKT136901 is an ?inhibitor of NOX1/4.It acts?as Selective and Direct Scavenger of Peroxynitrite.
  • Description
    GKT136901 is an ?inhibitor of NOX1/4.It acts?as Selective and Direct Scavenger of Peroxynitrite.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male db/db and db/m mice (8 weeks) Dosage:30, 90 mg/kg Administration:Daily p.o. for 16 weeks Result:Reduced albuminuria, thiobarbituric acid-reacting substances (TBARS) and renal ERK1/2 phosphorylation and preserved renal structure in diabetic mice.Had no effect on plasma glucose, BP (blood pressure), and body weight.
  • Synonyms
    AK120765
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NOX1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    955272-06-7
  • Formula Weight
    366.8
  • Molecular Formula
    C19H15ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (90.87 mM)
  • SMILES
    Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
  • Chemical Name
    2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[43-c]pyridine-36-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.S Schildknecht A Weber H R Gerding.The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite.Curr Med Chem. 2014;21(3):365-76.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GKT137831

    GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM.

  • Phloretic acid

    Phloretic acid is a phenolic compound. It can be used to produce polyesters based on phloretic acid and gallic acid.

  • 2-HBA

    2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.

Sign In Join Free