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2-HBA

CAS No. 131359-24-5

2-HBA( —— )

Catalog No. M20833 CAS No. 131359-24-5

2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    2-HBA
  • Note
    Research use only, not for human use.
  • Brief Description
    2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
  • Description
    2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
  • In Vitro
    When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NQO1|Caspase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    131359-24-5
  • Formula Weight
    266.29
  • Molecular Formula
    C17H14O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (375.53 mM)
  • SMILES
    O=C(/C=C/c1ccccc1O)/C=C/c1ccccc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dinkova-Kostova A T Cory A H Bozak R E et al. Bis(2-hydroxybenzylidene)acetone a potent inducer of the phase 2 response causes apoptosis in mouse leukemia cells through a p53-independent caspase-mediated pathway[J]. Cancer Letters 2007 245(1-2):0-349.
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