GIBH-130 ( GIBH 130;GIBH130 )

Catalog No. M11012 CAS No. 1252608-59-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GIBH-130
Note

Research use only, not for human use.
Brief Description

A novel inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM).
Description

A novel inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM); modulates the release of detrimental proinflammatory cytokines; exhibits in vivo efficacy of cognitive impairment in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models.Alzheimer's Disease Phase 1 Clinical
Synonyms

GIBH 130;GIBH130
Pathway

Others
Target

Other Targets
Recptor

IL-1β
Research Area

Neurological Disease
Indication

Alzheimer Disease

CAS Number

1252608-59-5
Formula Weight

360.42
Molecular Formula

C20H20N6O
Purity

>98% (HPLC)
Solubility

< 1 mg/ml refers to the product slightly soluble or insoluble
SMILES

O=C(C1=NN=C(C2=CC=CC=C2)C=C1C)N3CCN(C4=NC=CC=N4)CC3
Chemical Name

(4-methyl-6-phenylpyridazin-3-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone

1. Zhou W, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.

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