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GDP366
CAS No. 501698-03-9
GDP366 ( —— )
Catalog No. M26230 CAS No. 501698-03-9
GDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 471 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGDP366
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NoteResearch use only, not for human use.
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Brief DescriptionGDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18.
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DescriptionGDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18.(In Vitro):GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSeparase
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Research Area——
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Indication——
Chemical Information
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CAS Number501698-03-9
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Formula Weight375.5
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Molecular FormulaC20H17N5OS
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Do HT, Zhang N, Pati D, Gilbertson SR. Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4446-50.
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