Estradiol

CAS No. 50-28-2

Estradiol( β-Estradiol | Estradiol | 17β-Oestradiol | E2 )

Catalog No. M14702 CAS No. 50-28-2

Estradiol (E2) is a potent mammalian?estrogenic?hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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500MG 41 In Stock
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Biological Information

  • Product Name
    Estradiol
  • Note
    Research use only, not for human use.
  • Brief Description
    Estradiol (E2) is a potent mammalian?estrogenic?hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.
  • Description
    Estradiol (E2) is a potent mammalian?estrogenic?hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.
  • In Vitro
    Cell Differentiation Assay Cell Line:Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration:10 nM Incubation Time:7 days Result:Increased the number of neurite processes including neural differentiation and neurite branching.Immunofluorescence Cell Line:Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration:10 nM Incubation Time:7 days Result:Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.
  • In Vivo
    Animal Model:FBN-ARO-KO Mice Dosage:1 nM Administration:Treated for the hippocampal slices Result:Rescued long-term potentiation (LTP) amplitude of both male and female mice.Animal Model:FBN-ARO-KO Mice Dosage:0.0167 mg Administration:Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.Result:Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain. Rescued the spatial learning and memory defects.
  • Synonyms
    β-Estradiol | Estradiol | 17β-Oestradiol | E2
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    ER
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    50-28-2
  • Formula Weight
    272.38
  • Molecular Formula
    C18H24O2
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 5 mg/mL (18.35 mM); DMSO: 54 mg/mL (198.25 mM)
  • SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O
  • Chemical Name
    (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Takabe K, et al. J Biol Chem, 2010, 285(14), 10477-10486.
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