
Estradiol
CAS No. 50-28-2
Estradiol( β-Estradiol | Estradiol | 17β-Oestradiol | E2 )
Catalog No. M14702 CAS No. 50-28-2
Estradiol (E2) is a potent mammalian?estrogenic?hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.
Purity : >98% (HPLC)






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Biological Information
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Product NameEstradiol
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NoteResearch use only, not for human use.
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Brief DescriptionEstradiol (E2) is a potent mammalian?estrogenic?hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.
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DescriptionEstradiol (E2) is a potent mammalian?estrogenic?hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.
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In VitroCell Differentiation Assay Cell Line:Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration:10 nM Incubation Time:7 days Result:Increased the number of neurite processes including neural differentiation and neurite branching.Immunofluorescence Cell Line:Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration:10 nM Incubation Time:7 days Result:Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.
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In VivoAnimal Model:FBN-ARO-KO Mice Dosage:1 nM Administration:Treated for the hippocampal slices Result:Rescued long-term potentiation (LTP) amplitude of both male and female mice.Animal Model:FBN-ARO-KO Mice Dosage:0.0167 mg Administration:Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.Result:Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain. Rescued the spatial learning and memory defects.
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Synonymsβ-Estradiol | Estradiol | 17β-Oestradiol | E2
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorER
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Research AreaEndocrinology
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Indication——
Chemical Information
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CAS Number50-28-2
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Formula Weight272.38
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Molecular FormulaC18H24O2
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Purity>98% (HPLC)
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SolubilityEthanol: 5 mg/mL (18.35 mM); DMSO: 54 mg/mL (198.25 mM)
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SMILESC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O
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Chemical Name(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Takabe K, et al. J Biol Chem, 2010, 285(14), 10477-10486.
molnova catalog



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