GDC-0623 ( GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868 )

Catalog No. M17163 CAS No. 1168091-68-6

COA

Datasheet

HNMR

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Product Name

GDC-0623
Note

Research use only, not for human use.
Brief Description

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
Description

GDC-0623, also known as G-868, is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Synonyms

GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868
Pathway

Others
Target

Other Targets
Recptor

MEK1
Research Area

Cancer
Indication

——

CAS Number

1168091-68-6
Formula Weight

456.21
Molecular Formula

C16H14FIN4O3
Purity

98%
Solubility

DMSO : ≥ 30 mg/mL. 65.76 mM
SMILES

OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)N2C=NC=C2C=C1
Chemical Name

5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide