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FzM1
CAS No. 1680196-54-6
FzM1( Fzd4 modulator FzM1 | FzM 1 )
Catalog No. M12565 CAS No. 1680196-54-6
A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | Get Quote |
|
| 10MG | 98 | Get Quote |
|
| 25MG | 178 | Get Quote |
|
| 50MG | 335 | Get Quote |
|
| 100MG | 500 | Get Quote |
|
| 500MG | 1098 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameFzM1
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NoteResearch use only, not for human use.
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Brief DescriptionA negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism.
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DescriptionA negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism; induces conformational changes in Fz4 by interacting with the third intracellular loop, ICL3, inhibiting binding of dishevelled (Dsh) and hampering the formation of the Fz4-Dsh complex that is necessary for β-catenin nuclear transport and ultimately transcription of TCF/LEF-regulated genes.
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In Vitro——
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In Vivo——
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SynonymsFzd4 modulator FzM1 | FzM 1
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PathwayWnt/Notch/Hedgehog
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TargetFrizzled
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RecptorFrizzled
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Research Area——
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Indication——
Chemical Information
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CAS Number1680196-54-6
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Formula Weight360.43
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Molecular FormulaC21H16N2O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (173.40 mM)
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SMILESO=C(NC1=CC=C2C=CC=CC2=C1)NC3=CC(C4=CC=CS4)=CC(O)=C3
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Chemical Name1-(3-Hydroxy-5-(thiophen-2-yl)phenyl)-3-(naphthalen-2-yl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Generoso SF, et al. Nat Chem Biol. 2015 Apr;11(4):280-6.
2. Riccio G, et al. Biochemistry. 2018 Jan 2. doi: 10.1021/acs.biochem.7b01087.
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