Flubendazole

Research use only, not for human use.

Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.

Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.

Cell Viability AssayCell Line:CRC cells (HCT116, RKO and SW480).Concentration:0-400?μMIncubation Time:48?hResult:Effectively reduces the viability of CRC cells (HCT116, RKO and SW480) in a concentration-dependent manner, with an IC50 of 2-5?μM.Apoptosis Analysis Cell Line:CRC cells (HCT116, RKO and SW480).Concentration:0.3, 0.6, 1.2 μM Incubation Time:48?h Result:Increased the proportion of apoptotic cells in a dose-dependent manner. Dose-dependently effectively increases caspase-3 activity.Cell Autophagy Assay Cell Line:CRC cells (HCT116, RKO and SW480).Concentration:0.3, 0.6, 1.2 μM Incubation Time:24?h Result:Induced autophagy initiation by inactivating mTOR and P62, and upregulating LC3-I/II, which are classical marker of autophagy..Western Blot Analysis Cell Line:CRC cells (HCT116, RKO and SW480).Concentration:0.3, 0.6, 1.2 μM Incubation Time:24?h Result:Strongly reduced the expression of phosphorylated STAT3 (P-STAT3) in a dose and time-dependent manner. No obvious change in total STAT3 expression. Decreased expression of MCL1 and survivin in a dose-dependent manner.

Animal Model:Female BALB/c athymic nude mice (6-8?weeks) with HCT116 cells Dosage:10? or 30?mg/kg Administration:Intraperitoneal injection; every other day; 14 days Result:Markedly reduced the tumor volume. Significantly reduces the protein level of P-STAT3, promotes autophagy and induces apoptosis in vivo.

NSC 313680 | R-17889 | R-17899

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

microtubule

Infection

——

31430-15-6

313.29

C16H12FN3O3

>98% (HPLC)

DMSO: 1 mg/mL (3.19 mM)

O=C(OC)NC1=NC2=CC(C(C3=CC=C(F)C=C3)=O)=CC=C2N1

methyl (5-(4-fluorobenzoyl)-1H-benzo[d]imidazol-2-yl)carbamate

(-20℃)

With Ice Pack

≥ 2 years