Cart
sales@molnova.com
Floctafenine
CAS No. 23779-99-9
Floctafenine( —— )
Catalog No. M34258 CAS No. 23779-99-9
Floctafenine (R-4318) is an orally available nonsteroidal anti-inflammatory compound that is a COX-I and COX-2 inhibitor and interferes with the antiplatelet effects of aspirin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 445 | In Stock |
|
| 5MG | 686 | In Stock |
|
| 10MG | 938 | In Stock |
|
| 25MG | 1398 | In Stock |
|
| 50MG | 1822 | In Stock |
|
| 100MG | 2250 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameFloctafenine
-
NoteResearch use only, not for human use.
-
Brief DescriptionFloctafenine (R-4318) is an orally available nonsteroidal anti-inflammatory compound that is a COX-I and COX-2 inhibitor and interferes with the antiplatelet effects of aspirin.
-
DescriptionFloctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research.
-
In VitroFloctafenine (0.1-100 μM; in the presence of LPS; 24 hours) is slightly more potent 1.5-fold to inhibit in vitro platelet COX-I than monocyte COX-2. The IC50 values for platelet COX-I and monocyte COX-2 inhibition are 2.33 μM (95%CI) and 3.47 μM (95%CI), respectively in heparinized whole blood samples.Floctafenine (0.1-100 μM; in the presence of A23187; 1 hour) does not significantly affect A23187-caused LTB4 generation even up to 100 μM.
-
In VivoFloctafenine (intraperitoneal?injection; 50 mg/kg; single dose; 30 minutes prior to p-benzoquinone) has an inhibitory effects on p-benoquinone-induced writhing in rats, inhibition of writhing is 65.98%.
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetCOX
-
RecptorCOX
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number23779-99-9
-
Formula Weight406.36
-
Molecular FormulaC20H17F3N2O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(OCC(O)CO)C=1C=CC=CC1NC=2C=CN=C3C2C=CC=C3C(F)(F)F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. P Giuseppe, et al. Floctafenine: a valid alternative in patients with adverse reactions to nonsteroidal anti-inflammatory drugs. Ann Allergy Asthma Immunol. 1997 Jan;78(1):74-8.?
molnova catalog
related products
-
Tenidap
Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.
-
Mollugin
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway.
-
Tetrahydroamentoflav...
Tetrahydroamentoflavone is a potent XO inhibitor (IC50 = 92 nM, Ki = 982 nM) with anti-inflammatory effects. Tetrahydroamentoflavone can be used for studies about inflammation and gout.
