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Flecainide

CAS No. 54143-55-4

Flecainide ( Flecainide, Flecainida, Flecainidum, Tambocor, Apocard )

Catalog No. M14935 CAS No. 54143-55-4

A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Flecainide
  • Note
    Research use only, not for human use.
  • Brief Description
    A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart.
  • Description
    A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential; also inhibits ryanodine receptor 2 (RyR2), reduces calcium sparks and thus arrhythmogenic calcium waves in the heart.Heart Arrhythmia Approved
  • Synonyms
    Flecainide, Flecainida, Flecainidum, Tambocor, Apocard
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    54143-55-4
  • Formula Weight
    414.34
  • Molecular Formula
    C17H20F6N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F
  • Chemical Name
    N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hilliard FA, et al. J Mol Cell Cardiol. 2010 Feb;48(2):293-301.
2. Salvage SC, et al. Acta Physiol (Oxf). 2015 Jul;214(3):361-75.
3. Salvage SC, et al. Br J Pharmacol. 2017 Apr 3. doi: 10.1111/bph.13807.
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