Flecainide
CAS No. 54143-55-4
Flecainide( Flecainide, Flecainida, Flecainidum, Tambocor, Apocard )
Catalog No. M14935 CAS No. 54143-55-4
A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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100MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameFlecainide
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NoteResearch use only, not for human use.
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Brief DescriptionA class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart.
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DescriptionA class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential; also inhibits ryanodine receptor 2 (RyR2), reduces calcium sparks and thus arrhythmogenic calcium waves in the heart.Heart Arrhythmia Approved.
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In Vitro——
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In Vivo——
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SynonymsFlecainide, Flecainida, Flecainidum, Tambocor, Apocard
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorSodium Channel
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Research AreaCardiovascular Disease
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IndicationHeart Arrhythmia
Chemical Information
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CAS Number54143-55-4
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Formula Weight414.343
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Molecular FormulaC17H20F6N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (241.35 mM)
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SMILESO=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F
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Chemical NameN-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hilliard FA, et al. J Mol Cell Cardiol. 2010 Feb;48(2):293-301.
2. Salvage SC, et al. Acta Physiol (Oxf). 2015 Jul;214(3):361-75.
3. Salvage SC, et al. Br J Pharmacol. 2017 Apr 3. doi: 10.1111/bph.13807.
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