Flavopiridol
CAS No. 146426-40-6
Flavopiridol ( L-868275;HMR-1275;Alvocidib;NSC-649890 )
Catalog No. M11992 CAS No. 146426-40-6
A potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 47 | Get Quote |
|
10MG | 67 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameFlavopiridol
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
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DescriptionA potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively; inhibits cell cycle progression in either G1 or G2 in human breast carcinoma cells, induces programmed cell death, promote differentiation, inhibits angiogenic processes and modulates transcriptional events.Blood Cancer Phase 2 Clinical
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SynonymsL-868275;HMR-1275;Alvocidib;NSC-649890
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1;CDK2;CDK4;CDK6;CDK7
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number146426-40-6
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Formula Weight401.84
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Molecular FormulaC21H20ClNO5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
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Chemical Name4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. De Azevedo WF Jr, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40.
2. Carlson BA, et al. Cancer Res. 1996 Jul 1;56(13):2973-8.
3. Senderowicz AM, et al. Invest New Drugs. 1999;17(3):313-20.
4. Kim KS, et al. J Med Chem. 2000 Nov 2;43(22):4126-34.
2. Carlson BA, et al. Cancer Res. 1996 Jul 1;56(13):2973-8.
3. Senderowicz AM, et al. Invest New Drugs. 1999;17(3):313-20.
4. Kim KS, et al. J Med Chem. 2000 Nov 2;43(22):4126-34.
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