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Faldaprevir

CAS No. 801283-95-4

Faldaprevir( BI 201335 | BI201335 | BI-201335 )

Catalog No. M15999 CAS No. 801283-95-4

A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0 nM for GT1a and 1b NS3-NS4A protease, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Faldaprevir
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0 nM for GT1a and 1b NS3-NS4A protease, respectively.
  • Description
    A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0 nM for GT1a and 1b NS3-NS4A protease, respectively; also shows Ki of 2 to 230 nM for HCV GT2 to 6, potently inhibits HCV RNA replication in vitro of 6.5 and 3.1 nM in genotype 1a and 1b replicon assays, respectively; possesses good ADME profile in vitro and pharmacokinetics in vivo.HCV Infection Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BI 201335 | BI201335 | BI-201335
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    801283-95-4
  • Formula Weight
    869.829
  • Molecular Formula
    C40H49BrN6O9S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([C@]1(NC([C@H]2N(C([C@@H](NC(OC3CCCC3)=O)C(C)(C)C)=O)C[C@H](OC4=CC(C5=CSC(NC(C(C)C)=O)=N5)=NC6=C(Br)C(OC)=CC=C46)C2)=O)[C@H](C=C)C1)O
  • Chemical Name
    (1R,2S)-1-[[(2S,4R)-4-[8-bromo-7-methoxy-2-[2-(2-methylpropanoylamino)-1,3-thiazol-4-yl]quinolin-4-yl]oxy-1-[(2S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-2 ethenylcyclopropane-1-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Llinàs-Brunet M, et al. J Med Chem. 2010 Sep 9;53(17):6466-76. 2. White PW, et al. Antimicrob Agents Chemother. 2010 Nov;54(11):4611-8. 3. Manns MP, et al. J Hepatol. 2011 Jun;54(6):1114-22. 4. Zeuzem S, et al. Gastroenterology. 2011 Dec;141(6):2047-55; quiz e14.
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