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Ruzasvir

CAS No. 1613081-64-3

Ruzasvir( MK-8408 | MK 8408 | MK8408 )

Catalog No. M12336 CAS No. 1613081-64-3

A potent, pan-genotype HCV NS5A inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ruzasvir
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, pan-genotype HCV NS5A inhibitor.
  • Description
    A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.HCV Infection Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MK-8408 | MK 8408 | MK8408
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    1613081-64-3
  • Formula Weight
    947.1
  • Molecular Formula
    C49H55FN10O7S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC1=C(C(N2[C@H](C3=CN=C(C4CC4)S3)O5)=CC6=C2C=CC(C7=CN=C(C8N(C(C(NC(OC)=O)C(C)C)=O)CCC8)N7)=C6)C5=CC(C9=CN=C([C@H]%10N(C(C(NC(OC)=O)C(C)C)=O)CCC%10)N9)=C1
  • Chemical Name
    Dimethyl N,N'-([(6S)-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{(1H-imidazole-4,2-diyl)[(2S)-pyrrolidine-2,1- diyl][(2S)-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tong L, et al. J Med Chem. 2017 Jan 12;60(1):290-306. 2. Wyles D, et al. Hepatology. 2017 Dec;66(6):1794-1804. 3. Lawitz E, et al. Lancet Gastroenterol Hepatol. 2017 Nov;2(11):814-823.
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