FX1 ( FX-1;FX 1;BCL6 inhibitor FX1 )

Catalog No. M11798 CAS No. 1426138-42-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

FX1
Note

Research use only, not for human use.
Brief Description

A potent, specific BCL6 BTB domain inhibitor with Kd of 7 uM, binds with a greater affinity than the natural BCL6 ligand SMRT (Kd=30 uM).
Description

A potent, specific BCL6 BTB domain inhibitor with Kd of 7 uM, binds with a greater affinity than the natural BCL6 ligand SMRT (Kd=30 uM); exhibits 10-fold greater inhibitory activity against the BCL6 BTB domain in reporter assays with IC50 of 35 uM, displays good selectivity against a panel of 50 different kinases; disrupts formation of the BCL6 repression complex, reactivates BCL6 target genes, suppresses ABC-DLBCL cells in vitro and in vivo, as well as primary human ABC-DLBCL specimens ex vivo.
Synonyms

FX-1;FX 1;BCL6 inhibitor FX1
Pathway

Angiogenesis
Target

Bcl-2
Recptor

BCL-6
Research Area

——
Indication

——

CAS Number

1426138-42-2
Formula Weight

368.81
Molecular Formula

C14H9ClN2O4S2
Purity

>98% (HPLC)
Solubility

DMSO: 30 mg/mL, Need Ultrasonic （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(O)CCN(C/1=O)C(SC1=C2C(NC3=C/2C=C(Cl)C=C3)=O)=S
Chemical Name

(Z)-3-(5-(5-chloro-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid

1. Cardenas MG, et al. J Clin Invest. 2016 Sep 1;126(9):3351-62.
2. Deb D, et al. Cancer Res. 2017 Jun 1;77(11):3070-3081.

Calculator

molnova catalog