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CUDC-101
CAS No. 1012054-59-9
CUDC-101 ( CUDC101;CUDC 101 )
Catalog No. M10074 CAS No. 1012054-59-9
A potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 69 | In Stock |
|
| 25MG | 113 | In Stock |
|
| 50MG | 186 | In Stock |
|
| 100MG | 332 | In Stock |
|
| 500MG | 797 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCUDC-101
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
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DescriptionA potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively; Exhibits efficient antiproliferative activity with greater potency (IC50<1 uM) than Vorinostat (SAHA), Erlotinib, Lapatinib; Promotes tumor regression or inhibition in various cancer xenograft models including NSCLC, liver, breast, head and neck, colon, and pancreatic cancers. Solid TumorsPhase 1 Discontinued
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SynonymsCUDC101;CUDC 101
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorEGFR;HDAC;HDAC1;HDAC10;HDAC2;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9;HER2
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1012054-59-9
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Formula Weight434.49
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Molecular FormulaC24H26N4O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NO)CCCCCCOC1=CC2=C(NC3=CC=CC(C#C)=C3)N=CN=C2C=C1OC
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Chemical NameHeptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cai X, et al. J Med Chem. 2010 Mar 11;53(5):2000-9.
2. Lai CJ, et al. Cancer Res. 2010 May 1;70(9):3647-56.
3. Wang J, et al. Mol Cancer Ther. 2013 Jun;12(6):925-36.
2. Lai CJ, et al. Cancer Res. 2010 May 1;70(9):3647-56.
3. Wang J, et al. Mol Cancer Ther. 2013 Jun;12(6):925-36.
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