FR054

Research use only, not for human use.

FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival.

FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival.(In Vivo):The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects. FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. FR054 (250?μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells. FR054 induces endoplasmic reticulum stress and ROS-dependent apoptotic cell death .

——

Others

Other Targets

——

——

——

35954-65-5

657.6

C28H37N2O16

>98% (HPLC)

——

CC(OC[C@H]([C@H]1OC(C)=O)O[C@@H]2OC(C)=N[C@@H]2[C@H]1OC(C)=O)=OCC(OC[C@H]([C@H]1OC(C)=O)O[C@@H]2OC(C)=N[C@@H]2[C@H]1OC(C)=O)=O

——

(-20℃)

With Ice Pack

≥ 2 years