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FPH2

CAS No. 957485-64-2

FPH2( BRD-9424 )

Catalog No. M17692 CAS No. 957485-64-2

FPH2 (BRD-9424) is a small molecule promoting differentiation of iPS-derived hepatocytes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 68 In Stock
25MG 170 In Stock
50MG 295 In Stock
100MG 521 In Stock
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Biological Information

  • Product Name
    FPH2
  • Note
    Research use only, not for human use.
  • Brief Description
    FPH2 (BRD-9424) is a small molecule promoting differentiation of iPS-derived hepatocytes.
  • Description
    FPH2 (BRD-9424) is a small molecule promoting differentiation of iPS-derived hepatocytes.
  • In Vitro
    FPH2 induces functional proliferation of hepatocytes in vitro, and thus may be useful for expanding mature human primary hepatocytes. FPH1 and FPH2 can increase in hepatocyte nuclei count and/or elevate the number of nuclei undergoing mitosis during primary screening, and these effects on hepatocytes are concentration dependent. Cells treated with FPH1 and FPH2 also maintain their liver-specific functions. Over 7 days, FPH2 induces hepatocyte doublings at a rate that is consistent with reported liver regeneration kinetics in vivo.
  • In Vivo
    ——
  • Synonyms
    BRD-9424
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    957485-64-2
  • Formula Weight
    353.83
  • Molecular Formula
    C14H16ClN5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL; 353.28 mM
  • SMILES
    Clc1cc(NC(=S)Nc2cn(nc2C(=O)N)CC)c(OC)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shan J, et al. Nat Chem Biol. 2013, 9(8), 514-520.
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