Cart
sales@molnova.com
Home - Products - MAPK/ERK Signaling - p38 MAPK - SR-318

SR-318

CAS No. 2413286-32-3

SR-318( —— )

Catalog No. M26463 CAS No. 2413286-32-3

SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 Get Quote
5MG 80 Get Quote
10MG 132 Get Quote
25MG 267 Get Quote
50MG 430 Get Quote
100MG 620 Get Quote
500MG 1332 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SR-318
  • Note
    Research use only, not for human use.
  • Brief Description
    SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.
  • Description
    SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.(In Vitro):SR-318 shows anti-cancer and anti-inflammatory activity. SR-318 can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms, p38α/β.
  • In Vitro
    SR-318 presents a potent and selective type-II inhibitor of p38α/β that can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2413286-32-3
  • Formula Weight
    459.58
  • Molecular Formula
    C27H33N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (271.99 mM)
  • SMILES
    Nc(n(-c1ccccc1)nc1)c1C(NCc(cc1)ccc1C(NCCCC1CCCCC1)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Roux FA, Deschamps JY. Inadvertent intrathecal administration of ionic contrast medium to a dog. Vet Radiol Ultrasound. 2007 Sep-Oct;48(5):414-7. Review.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Losmapimod

    Losmapimod (GSK-AHAB, GW856553X, SB856553)?is a selective, potent, orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.

  • Veraguensin

    Veraguensin is derived from Magnolia sp.. Veraguensin inhibits bone resorption and shows high antileishmanial activity.

  • MW-150

    MW-150 (MW01-18-150 SRM) is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM.

Sign In Join Free