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SR-318

CAS No. 2413286-32-3

SR-318( —— )

Catalog No. M26463 CAS No. 2413286-32-3

SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SR-318
  • Note
    Research use only, not for human use.
  • Brief Description
    SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.
  • Description
    SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.(In Vitro):SR-318 shows anti-cancer and anti-inflammatory activity. SR-318 can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms, p38α/β.
  • In Vitro
    SR-318 presents a potent and selective type-II inhibitor of p38α/β that can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2413286-32-3
  • Formula Weight
    459.58
  • Molecular Formula
    C27H33N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (271.99 mM)
  • SMILES
    Nc(n(-c1ccccc1)nc1)c1C(NCc(cc1)ccc1C(NCCCC1CCCCC1)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Roux FA, Deschamps JY. Inadvertent intrathecal administration of ionic contrast medium to a dog. Vet Radiol Ultrasound. 2007 Sep-Oct;48(5):414-7. Review.
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